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Director's Awards Given for Outstanding Work IITRI Scientists Publish Research IITRI Scientists Transition into New Positions New Scientific and Administrative Staff Join IITRI
Director's Awards Given for Outstanding Work Two members of the IITRI staff were presented with Director's Awards in December 2006 for their outstanding contributions to IITRI's success:
IITRI Scientists Publish and Present Research Ya-Fei Chen, MD., MSc., Research Biologist in the Inhalation Toxicology Division, displayed his research findings in an abstract and poster presentation at the 46th annual meeting of the Society of Toxicology, March 25-29, 2007, in Charlotte, North Carolina. The abstract, entitled "Investigation of QT-Interval Prolongation in Conscious Telemetered Beagle Dogs With a Class III Antiarrhythmic Drug," presents a study conducted by Dr. Chen at IITRI in which the sensitivity of the in vivo method of safety pharmacology assessment of cardiovascular functions was evaluated. Also investigated was a method for quantifying beat-to-beat QT-intervals in a conscious free-moving telemetric canine model using an antiarrhythmic class III reference drug, d,l-sotalol. It was concluded that the conscious telemetered dog is a reliable pre-clinical model for detection of drug-induced ECG abnormalities. Michael Cwik, Ph.D., Senior Chemist in the Toxicology Division, collaborated with staff from the Department of Pharmacy Practice at the University of Illinois at Chicago to publish the manuscript entitled "Serum, tissue, and body fluid concentrations of tigecycline after a single 100 mg dose" in the Journal of Antimicrobial Chemotherapy [J. Antimicrob Chemother. 2006 Dec;58(6):1221-9]. The purpose of the study was to determine the tissue and corresponding serum concentrations of tigecycline at selected time points in the gall bladder, bile, colon, bone, synovial fluid, lung, and cerebrospinal fluid in subjects undergoing surgical or medical procedures. It was concluded that a single 100 mg dose of intravenous tigecycline produced considerably higher tissue/fluid concentrations in bile, gall bladder, colon, and lung compared with simultaneous serum concentrations. Thomas Horn, Ph.D., D.A.B.T., Research Toxicologist in the Toxicology Division, published the results of a study conducted at IITRI in an article entitled "Oncogenicity evaluation of resveratrol in p53(+/-) (p53 knockout) mice" in Food and Chemical Toxicology [Food Chem Toxicol. 2007 Jan;45(1):55-63]. The article details a six-month study conducted in p53(+/-) mice to evaluate the possible oncogenicity of resveratrol (3,5,4-trihydroxy-trans-stilbene), a cancer chemopreventive agent present in grapes and other foods. The article concludes that when administered to p53(+/-) mice at its maximum tolerated dose, resveratrol demonstrates no evidence of oncogenicity. Bruce Gingras, Ph.D., Senior Biologist and Section Head of Microbiology in the Microbiology and Molecular Biology Division, led a study in which a selective and differential plating medium, R & F anthracis chromogenic agar (ACA), was developed for isolating and identifying presumptive colonies of Bacillus anthraci. Margaret Juergensmeyer, Ph.D., Research Biologist, Microbiology and Molecular Biology Division, published Dr. Gingras' research in a manuscript entitled, "A selective chromogenic agar that distinguishes Bacillus anthraci from Bacillus cereus and Bacillus thuringiensis" in the Journal of Food Protection [J. Food Prot., 69, 2002-2006 (2006)]. Dr. Gingras' research discovered rapid differentiation on ACA of presumptive colonies of B. anthracis from B. cereus and B. thuringiensis in both pure and mixed cultures. Effective recovery of B. anthracis from a variety of matrices having both high and low microbial backgrounds with B. anthracis ANR-1 spores suggests the probable utility of ACA plating for B. anthracis recovery in a diversity of applications. ACA is frequently used by the Food and Drug Administration to test food for anthracis contamination. Margaret Juergensmeyer, Ph.D., Research Biologist in the Microbiology and Molecular Biology Dision, conducted research in which methyl bromide (MB), an agricultural fumigant used in the United States, was found capable of reducing or eliminating Bacillus anthracis spores. In the event of a bioterrorist attack, MB might serve as an excellent decontaminating agent, because it leaves no residue and does not damage furnishings and commodities. Dr. Juergensmeyer's manuscript, entitled "Methyl bromide fumigant lethal to Bacillus anthracis spores," discusses this research in the Journal of Environmental Health [J. Environ. Health, 69, 24-26 (2007)].
IITRI Scientists Transition into New Positions Tiffiney Glinsey and Ryan Hrejsa recently transitioned from their roles as laboratory biologists (both Laboratory Biologist II) in IITRI's Microbiology and Molecular Biology Division. Ms. Glinsey, who holds a B.S. in Biology from Northeastern Illinois University, now serves as an Associate Auditor in IITRI's Quality Assurance Unit. Mr. Hrejsa who earned his B.S. in Microbiology from the University of Illinois and an M.B.A. from IIT, now serves as a Business Development Associate for the Business Development group. Kristin Ulrich, formerly a Laboratory Biologist I in the Inhalation Toxicology division, recently joined the Report Writing team as an Associate Technical Editor. Ms. Ulrich graduated from St. Xavier University with a B.S. in Biology and earned her M.S. in Biology with a specialization in Biotechnology from IIT.
New Scientific and Administrative Staff Join IITRI The following scientific and administrative professionals recently joined the IITRI staff:
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