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Features
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Life Sciences Today |
Newsletter of the IIT Research Institute - Life Sciences Group |
Summer 2007 |
IITRI Scientists Publish Research Findings
Staff Members Celebrate Service Anniversaries
Director's Awards and Team Spirit Awards Given for Outstanding Work
IITRI Scientists Publish Research Findings
IITRI scientists have recently published several groundbreaking
cancer research studies. The following list contains work published from January 2006
through August 2007 (articles currently in Press will be featured at a later date):
Oncogenicity evaluations of chemopreventive soy components in p53(+/-) (p53 knockout) mice.
Inter. J. Toxicol., 25, 219-228, 2006. Johnson, W.D., Dooley, L., Morrissey, R.L., Arp, L., Kapetanovic, I., Crowell,
J.A. and McCormick, D.L.
Growth inhibition of carcinogen-transformed MCF-12F breast epithelial cells and hormone-sensitive BT-474
breast cancer cells by 1α-hydroxyvitamin D5. Carcinogenesis, 27, 551-559, 2006. Hussain-Hakimjee, E., Peng, X., Mehta, R.R. and
Mehta, R.G.
Inhibiting myosin light chain kinase retards the growth of mammary and prostate cancer cells. Eu. J. Cancer,
42, 947-957, 2006. Gu, L.Z., Hu, W.Y., Antic, N., Mehta, R., Turner, J.R. and de Lanerolle, P.
Ixocarpalactone A isolated from the Mexican tomatillo shows potent antiproliferative and apoptotic activity in
colon cancer cells. FEBS J., 273, 5714-5723, 2006. Choi, J.K., Murillo, G., Su, B.N., Pezzuto, J.M., Kinghorn, A.D. and Mehta, R.G.
Antioxidant xanthones from the pericarp of Garcinia mangostana (Mangostin). J. Agric. Food Chem., 54, 2077-2082, 2006.
Jung, H.A., Bao-Ning, S., Keller, W.J., Mehta, R.G., Kinghorn, A.D.
Prohibitin is a target gene of vitamin D involved in its antiproliferative action in breast cancer cells. Cancer Res., 66,
7361-7369, 2006. Peng, X., Mehta, R.R., Wang, S., Srikumar, C. and Mehta, R.G.
Hepatic activation of clinically relevant vitamin D analogs and prodrugs. Anticancer Res., 26, 2589-2596, 2006. Jones, G.,
Byford, V., West, S., Masuda, S., Ibrahim, G., Kaufmann, M., Knutson, J., Strgnell, S. and Mehta, R.
Chemoprevention of rat prostate carcinogenesis by 16α-fluoro-5-androsten-17-one (fluasterone), a minimally androgenic analog of
dehydroepiandrosterone. Carcinogenesis, 28, 398-403, 2007. McCormick, D.L., Johnson, W.D., Kozub, N.M., Rao, K.V.N., Lubet, R.A., Steele, V.E. and Bosland, M.C.
Oncogenicity evaluation of resveratrol in p53(+/-) (p53 knockout) mice. Food Chem. Toxicol., 45, 55-63, 2007. Horn, T.L., Cwik, M.J., Morrissey, R.L.,
Kapetanovic, I., Crowell, J.A., Booth, T.D. and McCormick, D.L.
Chemoprevention of rat prostate carcinogenesis by soy isoflavones and by Bowman-Birk inhibitor. Nutr Cancer, 57, 184-193, 2007. McCormick, D.L., Johnson, W.D.,
Bosland, M.C., Lubet, R.A. and Steele, V.E.
Null effect of dietary restriction on prostate carcinogenesis in the Wistar-Unilever Rat. Nutr Cancer, 57, 194-200, 2007. McCormick, D.L., Johnson, W.D.,
Haryu, T.M., Bosland, M.C., Lubet, R.A. and Steele, V.E.
Clinical trials with chemopreventive agents for the treatment of breast cancer. The Cancer J., 12, 445-450, 2007. Vijayakumar, S., Boerner, M.A., Mehta, R.R.,
Packianathan, S., Mehta, R.G. and Das Gupta, T.K.
Differential expression of prohibitin is correlated with dual action of vitamin D as a proliferative and antiproliferative hormone in breast epithelial cells.
J. Steroid Biochem. and Mol. Biol., 103, 446-450, 2007. Peng, X. and Mehta, R.G.
Chemopreventive efficacy of 25-hydroxyvitamin D3 in colon cancer. J. Steroid Biochem. Mol. Biol., 103, 763-767, 2007. Murillo, G., Matusiac, D., Benya, R.V.
and Mehta, R.G.
Inhibition of estrogen-independent mammary carcinogenesis by disruption of growth hormone signaling. Carcinogenesis, 28, 143-150, 2007. Zhang, X., Mehta, R.G.,
Lantvit, D.D., Coschigano, K.T., Kopchick, J.J., Green, J.E., Hedayat, S., Christov, K., Ray, V.H., Unterman, T.G. and Swanson, S.M.
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Staff Members Celebrate Service Anniversaries
Several staff members recently celebrated milestone service anniversaries with
IITRI:
35 Years
- Robert Gray, Biotechnician, Laboratory Animal Medicine
After 35 years, Bob Gray decided it was time to retire. Bob, thank you for your years of dedicated service to IITRI!
25 Years
- J. Brooks Harder, D.V.M., Senior Veterinarian, Laboratory Animal Medicine
5 Years
- Gail Dianis, B.S.M.T., Lab Biologist III, Clinical Pathology
- LaTanwa Fletcher, B.S., Data Coordinator, Inhalation Toxicology Division
- Scott Kraatz, B.S., Application Support and Test Engineer, Research Support Services
- Heidi Kreuzer, M.S., Research Technical Editor, Report Writing
- John Ogundele, B.S., Lab Biologist I, Toxicology Division
- Matthew Pytynia, B.S., Lab Biologist II, Inhalation Toxicology Division
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Director's Awards and Team Spirit Awards Given for Outstanding Work
Two members of the IITRI staff were presented with Director's Awards in July 2007 for
their outstanding contributions to IITRI's success:
Michael Hawthorne, M.S., Lab Biologist II for IITRI's Carcinogenesis and Chemoprevention Division,
was rewarded for his 22 years of service to IITRI. Everyone in both Mr. Hawthorne's group and outside the division
depend on Michael's assistance and appreciate his efficient, helpful and well-organized work ethic.
Guozheng Zhang, Ph.D., Senior Chemist, Analytical Chemistry Division, was rewarded for the substantial
amount of quality work he has produced for our Sponsors in recent months. In addition, he has been active in the development
and implementation of new analytical techniques, which has broadened IITRI's analytical chemistry capabilities. His commitment
and dedication to the organization are commendable.
The following IITRI staff members received Team Spirit Awards at the All Hands Meeting in July for their contributions
to the redesign of IITRI's logo:
Jeanne Banas
Elaine Brown
Michael O'Ryan
Tiffiney Smith
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