Metabolism and Pharmacokinetics

IITRI has extensive experience in the design and conduct of absorption, distribution, metabolism, and excretion (ADME) studies that include:

• Using a Wide Variety of In Vivo Models, Ranging from Rodents to Dogs to Primates.
• Using In Vitro Techniques Including Static and Dynamic Percutaneous Absorption Systems with Rodent and Human Skin.
• Using Various Routes of Administration Including Inhalation, Intravenous, Oral, and Dermal.
• Evaluating the Metabolism and Kinetics of Radio-Labeled Dosing Formulations and Determining the Mass Balance and Tissue/Organ Distribution of Dosing Formulations.
• Identifying Metabolites.
• Developing Pharmacokinetic Models.

The metabolism and pharmacokinetics laboratory is equipped with capabilities including; HPLC with in-line UV and radioactivity detectors, liquid scintillation counter, mass spectrometers, spectrophotometers, and specialized equipment for urine and feces collection.